On Different Methyl Derivatives of Hexathia-adamantane.
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چکیده
منابع مشابه
Synthesis and antimicrobial activity of new adamantane derivatives III.
Some novel ester imides synthesised from trimellitic acid anhydride and 1-adamantanol or 2-adamantanol, were tested as antimicrobial compounds. Unfortunately, these agents showed a modest antibacterial activity (MIC > 6 microg/ml). However, a comparison of these N-substituted adamantylester imides with the series published previously, indicated that the incorporation of L-alanine and L-phenylal...
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Marcy, R. et al.; J. Pharmacol. 13 (1), pp. 163-164 (1982). Miura, Y. et al.; Japan. J. Pharmacol. 39, pp. 443-451 (1986). Mi1tner, F. 0.; Arzneimittelforschung. 32 (10), pp. 1268-1270 (1982). Mi1tner, F. 0.; Arzneimittelforschung. 32 (10), pp. 1271-1273 (1982). Hamoen, A. M.; British Medical Journal. 3, (5874), pp. 272-273 (1973). Kinomota, H. et al.; No Skinkei Geka, 12 (1), pp. 37-45 (1984)....
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Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
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In this communication we present a new synthetic strategy to different generation Hydra-like dendrons based on tetrafunctionalized adamantane as a building block. The novel dendrons, which we termed HYDRAmers, possess at the periphery and at the central core orthogonal protections that can be exploited for conjugation of targeting ligands, drugs and/or imaging probes.
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Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1958
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.12-0366